Cyclic adenine nucleotide levels in lymphocytes from patients with systemic sclerosis: efficiency of prostaglandin infusions.
نویسندگان
چکیده
Basal intracellular cAMP levels of lymphocytes from patients with systemic sclerosis, all suffering from Raynaud's phenomenon, were significantly lower than those obtained from normal controls. Moreover, the cAMP response to isoprenaline of these patients' lymphocytes was inhibited. Intravenous infusion of prostaglandins (E1 and I2) restored the basal levels and greatly improved the responsiveness of the cells to isoprenaline stimulation.
منابع مشابه
Prostaglandin E1 infusions for vascular insufficiency in progressive systemic sclerosis.
Twelve patients with systemic sclerosis (SS) and severe Raynaud's phenomenon received infusions of prostaglandin E1 (PGE1) at a dose of 6-10 ng/kg/min, with either saline or 5% dextrose, for 72 hours in a single-blind cross-over study. The infusions were administered intravenously by centrally positioned catheters. Infusions were well tolerated with only mild side effects. Following the PGE1 in...
متن کاملSalivary Streptococcus mutans and Lactobacilli Levels as Indicators of Dental Caries Development in Iranian Patients with Systemic Sclerosis
Background and Objective: Systemic sclerosis is an autoimmune disorder with orofacial manifestations, including tooth decay. Lactobacilli can inhibit biofilm formation and growth of cariogenic pathogens, such as Streptococcus mutans. We aimed to assess the salivary levels of S. mutans and Lactobacilli as indicators of dental caries development in patients with systemic sclerosis. Methods: In t...
متن کاملEvaluation of Porin Interaction with Adenine Nucleotide Translocase and Cyclophilin-D Proteins after Brain Ischemia and Reperfusion
Objective (s) Porin is a mitochondrial outer membrane channel, which usually functions as the pathway for the movement of various substances in and out of the mitochondria and is considered to be a component of the permeability transition (PT) pore complex that plays a role in the PT. We addressed the hypothesis that porin interacts with other mitochondrial proteins after ischemic injury. Mater...
متن کاملHigh frequency skin ultrasonography in systemic sclerosis
Background: Systemic sclerosis is an autoimmune connective tissue disorder which is characterised by cutaneous and internal organ fibrosis. Raynaud’s phenomenon is the earliest feature and may precede the onset of the disease by months to years. The heart, lungs, gastrointestinal tract, kidneys and other organs may be involved. Our aim was to evaluate skin thickness and echogenicity in systemic...
متن کاملExpression of Chemokine Receptors on Th1/Th2 CD4+ Lymphocytes in Patients with Multiple Sclerosis
Background: Th1 cells preferentially express CXCR3, CCR5 and CCR6, while CCR3 and CCR4 are predominantly expressed by Th2 cell subsets. Multiple Sclerosis (MS) is a Th1 cell-dependant chronic inflammatory disease of the central nervous system, and immunomudolatory cytokines could alter the chemokine expression pattern of these lymphocyte subsets. Objective: This study was performed to measure c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Postgraduate medical journal
دوره 59 690 شماره
صفحات -
تاریخ انتشار 1983